Access to new bioactive molecules by development of original biocatalysts for reactions like "click chemistry"
RESULTS
RESEARCH REPORTS
I.S.I. PAPERS
2016
1. Aurel Tăbăcaru, Bianca Furdui, Ioana Otilia Ghinea, Geta Cârâc, Rodica Mihaela Dinică*, Recent Advances in Click Chemistry Reactions Mediated by Transition Metal Based Systems, InorganicaChimicaActa, 20 jul 2016, 10.1016/j.ica.2016.07.029 http://dx.doi.org/10.1016/j.ica.2016.07.029
2. Constantin O. E., Furdui B., Bahrim G., Dinică R. M. , Evaluation of the Antimicrobial Effects of New Heterocyclic Bis-Quaternary Ammonium Compounds on Biofilms, Scientific Study and Research, Chemistry and Chemical Engineering, Biotechnology, Food Industry, 2016, 17 (2), pp. 199 – 210, ISSN 1582-540X;
3. Horincar, Georgiana, Ghinea, Ioana Otilia, Furdui, Bianca, Dediu, Andreea Veronica, Bahrim, Gabriela, Dinica Rodica Mihaela , Evaluation of the biologic activity of some quaternary ammonium salts against non-pathogenic and pathogenic microorganisms, JOURNAL OF BIOTECHNOLOGY, 208, S104-S104, 2015, DOI: 10.1016/j.jbiotec.2015.06.326. http://www.mdpi.com/1420-3049/21/3/332
4. Simon Bonte , Ioana Otilia Ghinea, Rodica Dinica , Isabelle Baussanne, and Martine Demeunynck, Investigation of the Pyridinium Ylide—Alkyne Cycloaddition as a Fluorogenic Coupling Reaction, Molecules, 2016, 21(3), 332; doi: 10.3390/molecules21030332,
2015
1. Cârâc, A Boscencu, R. Dinică , R.M. Cârâc, G, Electrochemical behaviour of the new heterocyclic pyridinium ligands, Studia Universitatis Babes-Bolyai Chemia, 60, 3, 2015, Pages 99-109.
2. Ghinea, Ioana Otilia, Dediu, Andreea Veronica, Ungureanu, Claudia, Furdui, Bianca, Bahrim, Gabriela, Dinica Rodica Mihaela , Measuring the cytotoxicity of bioactive N-heterocyclic compounds obtained via enzymatic catalysis, JOURNAL OF BIOTECHNOLOGY, 208, S28-+, 2015, DOI: 10.1016/j.jbiotec.2015.06.076.
2014
1. Furdui B, Parfene G, Ghinea O., Dinica, R., Ghinea I. O., Bahrim G. and Demeunynck M., Synthesis and In Vitro Antimicrobial Evaluation of New N-Heterocyclic Diquaternary Pyridinium Compounds, Molecules, 2014, 19, ISSN 1420-3049,http://www.mdpi.com/1660-3397/11/2/431, if 2.697.
2. Claudia Simona Stefan, Oana Constantin, Carac G., Dinică R., Tutunaru D., Georgescu C., Imidazolium Octanoate Carboxylate as New Branching Agent in Lysozyme Crystallization, REV. CHIM. , 2014, 65, No. 8, if 0.530.
http://www.revistadechimie.ro/pdf/STEFAN%20C.pdf%208%2014.pdf
2013
1. Simon BONTE, Ioana Otilia GHINEA, Isabelle BAUSSANNE, Jean-Paul XUERE, Rodica Dinica, Investigation of the lipase catalysed reaction of aliphatic amines with ethylpropiolate as a route to N-substituted propiolamides, TETRAHEDRON, Volume 69, Issue 26, 1 July, 2013, ELSEVIER SCIENCE SA, http://dx.doi.org/10.1016/j.tet.2013.04.093,
ELSEVIER SCIENCE SA, if 3,25
http://www.sciencedirect.com/science/article/pii/S0040402013006534
2. R. M. DINICA, Bianca FURDUI, Ioana Otilia GHINEA, Gabriela BAHRIM, Simon BONTE and Martine DEMEUNYNCK, Novel One-Pot Green Synthesis of Indolizines Biocatalysed by Candida antarctica Lipases, MAR. DRUGS, 2013, 11(2), 431-439; doi: 10.3390/md11020431, if 3,84
http://www.mdpi.com/1660-3397/11/2/431
3. Georgiana PARFENE, Ioana Otilia GHINEA, Bianca FURDUI, Gabriela BAHRIM, Rodica Mihaela DINICA*, Screening and Biocatalytic Activity of Microbial Cells From Fungal Strains in Cycloaddition Processes, Current Opinion in Biotechnology, Volume 24, Supplement 1, Pages S1-S144 (July 2013), http://dx.doi.org/10.1016/j.copbio.2013.05.153
, if 3,25
http://www.sciencedirect.com/science/article/pii/S0958166913002693
2012
1. Bianca FURDUI, Rodica M. DINICA*, Aurel TABACARU, Claudio PETTINARI, Synthesis and physico-chemical properties of a novel series of aromatic electron acceptors based on N-heterocycles, TETRAHEDRON, 2012, ELSEVIER SCIENCE SA, doi: 10.1016/j.tet.2012.05.077, 
ELSEVIER SCIENCE SA, if 3,25
http://www.sciencedirect.com/science/article/pii/S0040402012007958
INTERNATIONAL CONFERENCES
2015
1. Ioana Otilia Ghinea, Bianca Furdui, Rodica M. Dinica , SCREENING AND BIOCATALYTIC ACTIVITY OF ENZYMES FROM PLANT CELLS IN CYCLOADDITION PROCESSES, BIOTRANS 2015, Vienna, Austria, 26 - 30 Jully, 2015. http://www.biotrans2015.com/programme/confirmed-poster-presentations/
2. Simona Patriche, Elena Georgiana Lupu, Andreea Cârâc, Rodica Mihaela Dinică and Geta Cârâc, ELECTROCHEMICAL INVESTIGATIONS OF LIPASE ENZYME ACTIVITY ON NEW PYRIDINIUM LIGANDS, 7 - 11 June, 2015, Pravets, Bulgaria. http://www.rse-see.eu/files/RSE-SEE5_PosterSessions.pdf
3. Ioana Otilia Ghinea, Mihaela Danaila, Madalina Costin, Bianca Furdui, Viorica Barbu, Rodica Mihaela Dinica , In vitro study to assess the influence of some N-heterocyclic compounds on germination, Symposium EuroAliment 2015, ALL ABOUT FOOD, 24-26 September 2015, Galati, Romania. http://www.euroaliment.ugal.ro/Programme%20EuroAliment%202015.pdf
4. Bianca Furdui, Ioana Otilia Ghinea, Rodica Mihaela Dinica , SPECTROSCOPIC STUDIES ON THE BINDING INTERACTION OF INDOLIZINE FLUOROPHORES TO DNA, Trans Mediterranean Colloquium on Heterocyclic Chemistry, TRAMECH VIII, 11-15 November 2015, Antalya, Turkey. http://www.tramech8.org/default.aspx?ID=4
5. Ghinea, Ioana Otilia, Dediu, Andreea Veronica, Ungureanu, Claudia, Furdui, Bianca, Bahrim, Gabriela, Dinica Rodica Mihaela , Measuring the cytotoxicity of bioactive N-heterocyclic compounds obtained via enzymatic catalysis, EUROPEAN BIOTECHNOLOGY CONGRESS, 7 – 9 May 2015, BUCHAREST
6. Horincar, Georgiana, Ghinea, Ioana Otilia, Furdui, Bianca, Dediu, Andreea Veronica, Bahrim, Gabriela, Dinica Rodica Mihaela , Evaluation of the biologic activity of some quaternary ammonium salts against non-pathogenic and pathogenic microorganisms, EUROPEAN BIOTECHNOLOGY CONGRESS, 7 – 9 May 2015, BUCHAREST http://www.eurobiotech2015.eu/?p=sprogram
2014
1. Parfene G., Ghinea I. O., Dinica R. M.* , Furdui B., Bahrim G., The Selection Of Lipase Producing Yeasts As Whole Cell Application For C–C Bond Formation In A “One-Pot” Synthesis, INTERNATIONAL CONFERENCE OF APPLIED SCIENCES , Eighth edition - MAY 7th – 9th 2014, BACAU, ROMANIA.
2. Ioana Otilia Ghinea, Simon Bonte, Rodica Mihaela Dinica1*, Bianca Furdui, Lidia Favier, and Martine Demeunynck, Antioxidant Potential of a New Family of Pyridinium Compounds, 3rd French-Romanian Colloquium on Medicinal Chemistry, 30-31 oct. 2014, Iasi, ROMANIA.
2013
1. Ioana Otilia GHINEA, Bianca FURDUI, Georgiana PARFENE, Gabriela BAHRIM, Rodica Mihaela DINICA*, 1,3-DIPOLAR CYCLOADDITIONS CATALYZED BY HORSERADISH ENZYMES, IUPAC Congres, 11-16 August 2013, Istambul, Turkey, http://www.iupac2013.org
2. Bianca FURDUI, Ioana Otilia GHINEA, Steluta GOSAV, Rodica Mihaela DINICA*, SYNTHESIS AND PHOTOPHYSICS OF SOME NEW INDOLIZINES FLUOROPHORES, IUPAC Congres, 11-16 August 2013, Istambul, Turkey, http://www.iupac2013.org
3. Ioana Otilia GHINEA, Georgiana PARFENE, Rodica-Mihaela DINICA*, Bianca FURDUI, Gabriela BAHRIM, Simon BONTE, Martine DEMEUNYNCK, Combined Action of Enzymes and Ultrasounds: the First “One-Pot” Cycloaddition Reaction for Indolizine Synthesis, 2nd International Symposium on Green Chemistry: Renewable Carbon and Eco-efficient Processes (ISGC2), May 21-24th, 2013, La Rochelle, France, www.isgc2013.com
4. Georgiana PARFENE, Ioana Otilia GHINEA, Bianca FURDUI, Gabriela BAHRIM, Rodica Mihaela DINICA*, Screening and Biocatalytic Activity of Microbial Cells From Fungal Strains in Cycloaddition Processes, European Biotechnological Congres, 16-18 May, 2013, Bratislava, Slovakia, http://www.eurobiotech2013.eu
5. P.NECHITA, R.M.DINICĂ*, A.M. AXINTE, C. STANCIU, Applications of n-heterocyclic compounds on functionalising of fibre based materials, INTERNATIONAL CONFERENCEOF APPLIED SCIENCES CHEMISTRY AND CHEMICAL ENGINEERING - Seventh Edition, MAY 15th –18th 2013, BACĂU, ROMÂNIA
6. I.O.GHINEA, R.M.DINICA*, G.BAHRIM, G.CARAC, Electro-oxidation of New Pyridine Ring Heterocycles on Platinum Electrode in Aqueous Medium, 19-24 August 2012, 63rd, Annual Meeting of the International Society of Electrochemistry, Praga, Cehia, http://event12.ise-online.org/index.php
2012
1. Julien DEBRAY, Simon BONTE, Rodica M.DINICA*, Martine DEMEUNYNCK, Vers une synthèse plus verte de quinazolin-4-ones biologiquement actives, Septième Colloque Franco-Roumain de Chimie Appliquée - COFrRoCA–2012, 27 – 29 Juin 2012, Bacău, Roumanie, http://cisapm.inginerie.ub.ro/evenimente/83-cofrroca-2012
2. Georgiana PARFENE, Bianca FURDUI, Mariana LUPOAIE, Rodica Mihaela DINICĂ*, Cellules vegetales utilisees comme biocatalyseurs dans les reactions, Actes du septieme colloque franco-romain de chimie appliquee, iunie 2012, http://cisapm.inginerie.ub.ro/evenimente/83-cofrroca-2012
3. Ionuţ TĂBĂCARU, Gabriela GURĂU, Bianca FURDUI, Rodica Mihaela DINICĂ*, Etudes sur l’activité antimicrobienne des nouveaux sels diquaternaires de bis-pyridinium, Septième Colloque Franco-Roumain de Chimie Appliquée - COFrRoCA – 2012, 27 – 29 Juin 2012, Bacău, Roumanie http://cisapm.inginerie.ub.ro/evenimente/83-cofrroca-2012
4. Rodica M. DINICĂ*, Bianca FURDUI, Oana GHINEA, Une synthese facile et efficace “one pot” des derives indoliziniques en milieu de reaction écologique, Septième Colloque Franco-Roumain de Chimie Appliquée - COFrRoCA – 2012, 27 – 29 Juin 2012, Bacău, Roumanie, http://cisapm.inginerie.ub.ro/evenimente/83-cofrroca-2012
5. R. M. DINICA*, B. FURDUI, G. PARFENE, G. BAHRIM, A one-pot synthesis of substituted bis-indolizines using microbial cells, Challenges in Bioorganic & Organic Medicinal Chemistry: 13th Tetrahedron Symposium, 26 - 29 June, 2012, Amsterdam, The Netherlands, http://www.nature.com/natureevents/science/events/1257413th_Tetrahedron_Symposium_Challenges_in_Bioorganic_Organic_Medicinal_Chemisty
6. Rodica M.DINICA*, Bianca FURDUI, Geta CÂRÂC, Electrochemical Behavior in aprotic medium of pzridinium salt, Third Regional Symposium on Electrochemistry South-East Europe, București, 13-17 mai, 2012
7. Ioana Otilia GHINEA, Gabriela BAHRIM, Rodica M. DINICA*, Martine Demeunyck, "Green" preparation of Fluorescent dyes using cell extracts for enzymatic catalysis Rencontres en Chimie Organique Biologique, Recob14, 2012, CENTRE PAUL LANGEVIN, AUSSOIS (SAVOIE),18 - 22 Mars 2012, http://www.recob-tlse.org/
BOOKS
2015
Ioana Otilia Ghinea, Rodica Mihaela Dinica , Breakthroughs in indole and indolizine chemistry - new synthetic pathways, new applications, in book: Scope of Novel Heterocycles from Organic and Pharmaceutical Perspective, Intech, open acces, ISBN: 978-953-51-4632-2, http://www.intechopen.com/.
2014
Geta Cârâc, Claudia Simona Ştefan, Electrochemistry. Fundamental principles and applications, Editura GUP, 2014, Galați, ISBN: 978-606-8348-64-3, Monografie sumară, teaching material for PhD candidates, postgraduate students, undergraduates students and teaching staff, specialists in chemistry, food engineering, pharmaceutical sciences, material science etc.
PROJECT WON
2014
Cost Action -Active and intelligent fibre-based packaging - innovation and market introduction- COST FP1405 ActInPak, oc-2014-1-18987
SCIENTIFIC EVENTS 2016
EUROPEAN BIOTECHNOLOGY CONGRESS 2016, RIGA, LATVIA,05 - 07 May 2016.
17TH TETRAHEDRON SYMPOSIUM, Challenges in Biological, Bioorganic, Organic & Medicinal Chemistry, 28 June - 1 July 2016 | Sitges (near Barcelona), Spain
ECOSUMMIT 2016 [1], ECOLOGICAL SUSTAINABILITY: ENGINEERING CHANGE Le Corum, Montpellier, France, 29 August - 1 September 2016.
INTERNATIONAL COLABORATION PROJECTS SUSTINED
Bilateral colaboration Romania - France 2011-2013
Programme „Hubert Curien- Brancusi” nr. 485/17.03.2011, Accesul la noi molecule bioactive prin dezvoltarea unor biocatalizatori originali pentru reacţii tip „click-chemistry”.
Parteners: University Dunarea de Jos of Galati - Conf. dr. Dinica Rodica Mihaela
University Joseph Fourier, Grenoble, Département Pharmacochimie Moléculaire - Director CNRS Martine Demeunynck
Bilateral colaboration Romania - France 2013-2015
Development and implementation of efficient processes for pharmaceutical compounds bioremediation, PN-II-CT-RO-FR-2012-1-0023
Parteners: University Dunarea de Jos of Galati - Prof.dr. ing. Gabriela Bahrim
Sciences Chimiques de Rennes - Chimie et Ingénierie des Procédés
Bilateral colaboration Romania - China 2013-2015
Utilizarea de tulpini fungice selectate pentru a obţine antimicrobieni cu impact mare în asigurarea siguranţei alimentare
Parteners: University Dunarea de Jos of Galați – Prof.dr. ing. Gabriela Bahrim
Research Chinez National Institute for Food and Fermentation - Dr. WANG Deliang